23+ I Motif

23+ I Motif

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I Motif

Preferential targeting cancer related i motif DNAs by the Sumber : www.nature.com

I motif DNA structures are formed in the nuclei of
01 06 2000 The i motif can also be formed in a dimer of a DNA strand containing two cytidine stretches and an intermediate linker e g 5mCCT 3 AC 2 or again by intramolecular folding of a single strand with four cytidine stretches The intercalation and loop topologies are sensitive to the linker sequence 13 14 Symmetries or quasi symmetries may give rise to multiple structures

I motif DNA structures are formed in the nuclei of human Sumber : www.nature.com

i motif DNA Wikipedia
The i motif represents a paradigmatic example of the wide structural versatility of nucleic acids In remarkable contrast to duplex DNA i motifs are four stranded DNA structures held together by hemi protonated and intercalated cytosine base pairs C C First observed 25 years ago and considered by many as a mere structural oddity interest in and discussion on the biological role of i motifs have

Scientists confirm weird knot shaped DNA structure in Sumber : www.zmescience.com

i Motif DNA structural features and significance
15 08 2014 i Motif structure consists of two wide grooves and two very narrow grooves Consequently there is repulsion between adjacent negatively charged phosphate backbones that define the minor groove this needs to be balanced for i motifs to be stable Molecular dynamics simulations have been used to investigate the effect of phosphate repulsion on the stability of the 5 E and 3 E topologies of

I motif A Completely New DNA Structure In Human Cells Sumber : www.rankred.com

The RNA i motif PubMed
05 03 2022 The i motif is a four stranded structure formed by intercalated hemiprotonated C C base pairs under acidic conditions 4 6 or at neutral pH 7 8 by the molecular crowding of the co solutes or at high pressure The i motif structure has been found in the promoter of many genes and can regulate gene transcription in cell lines 6 9 10 14

Folding topology of the human telomeric DNA i motif A Sumber : www.researchgate.net

In vivo visualization of the i motif DNA secondary
30 08 2022 The ds i motif bio was easily attached to Exo strep to form i motif coated exosomes Exo i motif Fig 1C Dox was intercalated into the double stranded I motif DNA on the surfaces of the exosomes Exo i motif Dox In previous studies the structure of the i motif could be easily regulated by the pH of its environment Accordingly it was hypothesized that Exo i motif Dox could deliver Dox in a

I motif A Completely New DNA Structure In Human Cells Sumber : www.rankred.com

The i motif in nucleic acids ScienceDirect
Oligodeoxynucleotides with stretches of cytidine residues associate into a four stranded structure the i motif in which two head to tail intercalated parallel stranded duplexes are held together by hemiprotonated C C pairs We have investigated the possibility of forming an i motif structure with C rich ribonucleic acids The four C rich RNAs studied r UC5 r C5 r C5U and r UC3 associate into

The importance of loop length on the stability of i motif Sumber : pubs.rsc.org

i Motif DNA structural features and significance
19 09 2022 The i motif represents a paradigmatic example of the wide structural versatility of nucleic acids In remarkable contrast to duplex DNA i motifs are four stranded DNA structures held together by hemi protonated and intercalated cytosine base pairs C C First observed 25 years ago and considered by many as a mere structural oddity interest in and discussion on the biological role of i motifs

Molecules Free Full Text Fluorescent Sensor for PH Sumber : www.mdpi.com

i Motif DNA Structure stability and targeting with
23 04 2022 I motif structures are thought to form in cytosine rich regions of the genome and to have regulatory functions however in vivo evidence for the existence of such structures has so far remained

I motif stapled and spacer dependent multiple DNA Sumber : pubs.rsc.org

I motif coated exosomes as a pH sensitive carrier
28 05 2022 Cytosine rich single stranded DNA oligonucleotides are able to adopt an i motif conformation a four stranded structure near a pH of 6 This unique pH dependent conformational switch is reversible and hence can be controlled by changing the pH Here we show that the pH response range of the human telomeric i motif can be shifted towards more basic pH values by introducing 5